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Updated: Aug 24, 2026
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Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Administration of FGF-1 through transfected cells alleviates MPTP toxicity in mice
R N McLay1, S M Freeman, J E Zadina
1Tulane University School of Medicine and New Orleans V.A. Medical Center, New Orleans, LA 70152, USA. james.zadina@tulane.edu
Neurotoxicity Research
|April 28, 2004
Abstract:
The use of genetically modified cells to deliver growth factors has been proposed as a possible treatment for neurodegeneration, including Parkinson's disease. Here we demonstrate that the implantation of fibroblasts genetically modified to secrete fibroblast growth factor-1 (FGF) increased striatal dopamine concentrations in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse model of Parkinson's disease.
