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Related Experiment Videos

Elastic instability in growing yeast colonies.

Baochi Nguyen1, Arpita Upadhyaya, Alexander van Oudenaarden

  • 1Department of Mathematics and Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Biophysical Journal
|April 28, 2004
PubMed
Summary

Cell adhesion drives tissue formation by minimizing energy. However, this study shows growing tissues can become unstable, defying energy minimization due to competing elastic and surface forces.

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Area of Science:

  • Biophysics
  • Developmental Biology
  • Cellular Mechanics

Background:

  • Differential cell adhesion is considered a primary mechanism for tissue formation.
  • The prevailing hypothesis suggests cell aggregates achieve stability by minimizing surface adhesive energy.

Purpose of the Study:

  • To investigate conditions where tissue formation deviates from the principle of minimizing adhesive energy.
  • To explore the role of competing energies in tissue shape instability.

Main Methods:

  • Utilized a model experimental system to observe tissue growth dynamics.
  • Developed a mathematical model to analyze the forces governing tissue shape.

Main Results:

  • Demonstrated that slowly growing tissues can exist under conditions that do not minimize adhesive energy.

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  • Identified the instability of spherical tissue shapes resulting from a balance between elastic and surface energies.

    • Conclusions:

    • The principle of minimizing adhesive energy may not universally apply to all stages of tissue formation.
    • Elastic and surface energy competition can drive morphological instabilities in developing tissues.