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c-myb and growth control.

B Calabretta1, N C Nicolaides

  • 1Department of Microbiology, Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107.

Critical Reviews in Eukaryotic Gene Expression
|January 1, 1992
PubMed
Summary
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The c-myb gene regulates cell proliferation in hematopoietic and nonhematopoietic cells through autoregulation and interaction with other factors. Its family members, like B-myb, also play crucial roles in cell cycle progression.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • The c-myb gene is crucial for hematopoietic cell proliferation and is expressed in certain nonhematopoietic cells.
  • Regulation of c-myb expression involves a positive autoregulatory mechanism and tissue-specific transcription.
  • Other transactivating factors, such as Jun family members, also influence c-myb expression levels.

Purpose of the Study:

  • To elucidate the regulatory mechanisms of c-myb gene expression.
  • To understand the role of c-myb in cell proliferation and its interaction with other genes.
  • To investigate the broader role of the myb gene family in cell cycle regulation.

Main Methods:

  • Analysis of the positive autoregulatory mechanism of c-myb.
  • Investigation of transcriptional regulation involving the 5' flanking region of the human c-myb gene.

Related Experiment Videos

  • Examination of the interaction between myb protein and gene promoters, including DNA polymerase-alpha and cdc2.

    • Main Results:

    • Positive autoregulation, involving myb protein interaction with the c-myb gene's 5' flanking region, is critical for high transcript levels.
    • Factors like Jun family members may cooperate with myb to regulate c-myb transcription.
    • Genes essential for DNA synthesis (DNA polymerase-alpha, cdc2) show myb binding sites, suggesting myb's role in their transactivation.
    • The myb family, including the ubiquitous B-myb, plays a general role in regulating cell proliferation and cdc2 expression.

    Conclusions:

    • c-myb and its family members are key regulators of cell proliferation.
    • Autoregulation and interactions with other factors ensure sufficient c-myb levels for biological activity.
    • The myb family's role in cell cycle progression, particularly through regulating genes like cdc2, is broadly significant.