Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple primary malignancies.

Andrea Luciani1, Lodovico Balducci

  • 1Unità Operativa di Oncologia Medica, Ospedale S. Paolo-Milano, via Europa 3, 20077 Melegnano, Milan, Italy.

Seminars in Oncology
|April 28, 2004
PubMed
Summary

Age is a risk factor for multiple primary malignancies, with risk increasing with age. However, no specific phenotype identifies older individuals at higher risk, though older women face increased risk for endometrial and breast cancers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Refining chemotherapy decision-making in older adults: A prospective validation of a simplified two-level CARG score classification (CARG-8).

Journal of geriatric oncology·2026
Same author

Strengthening partnerships, accountability, resource mobilisation for better health outcomes in Africa: the example of the WHO Africa Regional Office Transformation Agenda.

BMJ public health·2026
Same author

Neutropenic events associated with new anticancer treatments, from pathophysiology to practice: a scoping review-NEW Group (Neutropenic Events Working Group).

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2025
Same author

Partnership for health promotion as a platform to improve public health outcomes in Small Island Developing States: a case study of the Union of the Comoros.

Frontiers in public health·2025
Same author

EORTC 1417 - REACTION: A phase II study of etoposide and cis/carboplatin with or without pembrolizumab in untreated extensive small cell lung cancer.

European journal of cancer (Oxford, England : 1990)·2025
Same author

Reassessing the Evidence: Is Intensified Therapy Justified in Older Patients with Metastatic Hormone-Sensitive Prostate Cancer?

Clinical genitourinary cancer·2025

Area of Science:

  • Gerontology
  • Oncology
  • Epidemiology

Background:

  • Cancer incidence and prevalence rise with age.
  • This suggests an increased likelihood of multiple primary malignancies in older populations.
  • Investigating age as a risk factor and identifying susceptible phenotypes is crucial.

Purpose of the Study:

  • To determine if age is a risk factor for multiple primary malignancies.
  • To ascertain if a specific phenotype of older individuals is at increased risk.
  • To explore age-related patterns in cancer development.

Main Methods:

  • Analysis of autopsy series.
  • Review of tumor registry data.
  • Examination of age-specific cancer risks.

Main Results:

  • Prevalence and risk of multiple primary malignancies increase with age.
  • No distinct phenotype was identified for increased risk in older individuals.
  • A potential increased risk of endometrial cancer with breast cancer in women aged 70+ was observed.

Conclusions:

  • Age is a significant factor in the development of multiple primary malignancies.
  • Current data do not allow for the identification of specific high-risk phenotypes in older adults.
  • Limitations in data sources necessitate further prospective research, including genetic and cytokine analysis, for a clearer understanding.

Related Experiment Videos