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Related Experiment Videos

Combined discrete particle and continuum model predicting solid-state fermentation in a drum fermentor.

M A I Schutyser1, W J Briels, R M Boom

  • 1Wageningen Centre for Food Sciences, P.O. Box 557, 6700 AN Wageningen, The Netherlands.

Biotechnology and Bioengineering
|April 28, 2004
PubMed
Summary

A new two-phase mathematical model for solid-state fermentation (SSF) was developed. This model reveals that poor air distribution in large-scale drum fermentors limits biomass yield due to temperature gradients.

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Area of Science:

  • Biochemical Engineering
  • Process Modeling
  • Industrial Biotechnology

Background:

  • Mathematical models are crucial for scaling up solid-state fermentation (SSF) processes.
  • Previous models often simplified the complex interactions within fermentors.
  • Understanding heat and mass transfer is key to optimizing SSF performance.

Purpose of the Study:

  • To develop and validate a two-phase mathematical model for drum fermentors used in SSF.
  • To investigate the impact of fermentor scale on temperature distribution and biomass yield.
  • To identify limitations in current aeration strategies for large-scale SSF.

Main Methods:

  • A two-phase model combining a discrete particle model (solid phase) and a continuum model (gas phase) was developed.

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  • The model incorporated heat and mass transfer between phases and biomass growth.
  • Model validation was performed using experimental data from a 28-dm3 drum fermentor.

    • Main Results:

    • Simulations indicated that forced aeration via a single pipe leads to non-homogeneous cooling in the substrate bed.
    • Significant temperature gradients were observed, severely decreasing biomass yield with increasing fermentor size.
    • The model predicted that improved air distribution is necessary to maintain optimal growth temperatures and avoid frequent mixing.

    Conclusions:

    • The developed two-phase model is a valuable tool for analyzing and optimizing the design and scale-up of aerated SSF fermentors.
    • Current aeration methods are insufficient for large-scale SSF, necessitating improvements in air distribution.
    • Addressing temperature gradients through better aeration is critical for enhancing biomass yield in industrial SSF applications.