Detection of polyomavirus DNA in human brain tumors
Iryna G Vasilyeva1, Mikhail I Shamaev, Alexandr Ya Glavatskiy
1A.P. Romodanov Institute of Neurosurgery of Academy of Medical Sciences of Ukraine, Kyiv, Ukraine. ira@neuro.kiev.ua
Aim:
To investigate surgically resected human brain tumors for the presence of polyomavirus DNA.
Materials And Methods:
65 samples of surgically resected human brain tumors (57 tumors were of neuroectodermal genesis, 4--mesenchimal, 4--metastatic tumors) were examined for the presence of viral DNA by PCR analysis.
Results:
DNA of polyomaviruses was found in oligodendroligomas (66.7% of cases), oligodendroastrocytomas (66.7% of cases) and glioblastomas (40% of cases). In metastatic tumors viral infection had not been detected. No correlation between the grade of brain tumors and infection with polyomavirus DNA has been revealed.
Conclusion:
Our data point to importance of investigation of the brain tumors and cerebrospinal fluid for determination of viral infection.
