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Published on: June 11, 2012
The use of a continuous glucose monitoring system in hypoglycemic disorders
Susan C Conrad1, John J Mastrototaro, Stephen E Gitelman
1Department of Pediatrics, University of California at San Francisco, San Francisco 94143, USA.
Insights
Continuous glucose monitoring systems (CGMS) aid in diagnosing and managing hypoglycemia in children. This technology helps document normal glucose levels after treatment.
Area of Science:
- Pediatric Endocrinology
- Medical Device Technology
Background:
- Hypoglycemic disorders in infants and children require accurate monitoring.
- Continuous Glucose Monitoring Systems (CGMS) offer potential for improved glucose assessment.
Purpose of the Study:
- To assess the utility of CGMS in evaluating and treating pediatric hypoglycemic disorders.
- To compare CGMS data with capillary blood glucose (CBG) measurements.
Main Methods:
- CGMS devices were used by five pediatric patients with hypoglycemic disorders.
- Device calibration involved daily CBG readings.
- Hypoglycemic episodes were identified and characterized by duration and intensity.
Main Results:
- 180 hypoglycemic episodes were recorded over 57 days.
- CGMS demonstrated 65.4% sensitivity and 90.6% specificity for hypoglycemia detection (cutoff 3.3 mmol/l).
- Positive and negative predictive values were 57.1% and 93.2%, respectively.
Conclusions:
- CGMS is a valuable tool for diagnosing and evaluating hypoglycemia in pediatric patients.
- The system aids in documenting euglycemia following therapeutic interventions.
Objective:
To evaluate the use of a continuous glucose monitoring system (CGMS) in the evaluation and treatment of infants and children with hypoglycemic disorders.
Methods:
Patients with hypoglycemic disorders wore the CGMS device in the Pediatric Clinic Research Center during their evaluation and treatment. Capillary blood glucose (CBG) values were obtained at least 3 times each day and entered into the device for calibration purposes. We evaluated the number of hypoglycemic episodes below 3.3 mmol/l (60 mg/dl) detected by CGMS compared to CBG values and characterized episodes by their duration and intensity.
Results:
Five patients with hypoglycemic disorders were included in the study. There were a total of 13,369 sensor points, 343 paired sensor and CBG data points, and 57 days included. A total of 180 episodes of hypoglycemia occurred in these five patients, with an average duration of 55 +/- 13 minutes. Using a cut-off of 3.3 mmol/l (60 mg/dl) for hypoglycemia, the sensor had a sensitivity of 65.4%, specificity of 90.6%, and false positive rate of 42.9%. The positive and negative predictive values were 57.1% and 93.2%, respectively.
Conclusion:
CGMS is a useful adjunct in the diagnosis and evaluation of hypoglycemia, and for documentation of euglycemia in these patients following therapy.
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