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Related Experiment Videos

Immunosuppression: practice and trends.

Dixon B Kaufman1, Ron Shapiro, Michael R Lucey

  • 1Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. d-kaufman2@northwestern.edu

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|April 29, 2004
PubMed
Summary
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Immunosuppression therapy has evolved with new drugs and antibodies, shifting from cyclosporine to tacrolimus and reducing antibody use for rejection. These changes have improved short-term transplant outcomes.

Area of Science:

  • Transplant Medicine
  • Immunology
  • Pharmacology

Background:

  • Immunosuppression therapy has rapidly evolved over the past decade.
  • New immunosuppressive molecules and antibodies are increasingly used in transplant medicine.

Purpose of the Study:

  • To review organ-specific trends in immunosuppression therapy.
  • To analyze changes in induction therapy, maintenance immunosuppression, and rejection treatment.

Main Methods:

  • Organ-by-organ data review.
  • Analysis of immunosuppression drug usage patterns (induction, maintenance, rejection).
  • Comparison of drug choices across different transplant types (kidney, liver, heart, etc.).

Main Results:

Related Experiment Videos

  • Highest induction therapy use in simultaneous pancreas kidney (SPK) and pancreas after kidney (PAK) transplants (>70%).
  • Corticosteroids were common maintenance immunosuppression (87% for kidney, SPK, PAK, thoracic).
  • Shift from cyclosporine to tacrolimus for maintenance immunosuppression in most organs by 2001, except heart and intestine transplants.
  • Decreased use of antibody treatment for rejection in the first post-transplant year.
  • Improved short-term outcomes with diminished first-year rejection rates.

    • Conclusions:

    • Significant changes in immunosuppression protocols have occurred.
    • Tacrolimus is now the predominant calcineurin inhibitor for most organs.
    • Reduced antibody use and improved short-term outcomes indicate progress in transplant medicine.