Related Experiment Video
Updated: Aug 24, 2026

Murine Model of Epicutaneously-Induced Immunomodulation
Published on: June 24, 2025
Prostanoids in the cutaneous immune response
Kenji Kabashima1, Yoshiki Miyachi
1Department of Dermatology, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. kaba@kuhp.kyoto-u.ac.jp
Abstract:
Prostanoids, consisting of the prostaglandins and the thromboxanes, are the cyclooxygenase metabolites of arachidonic acid. They exert a range of actions mediated by their respective receptors expressed in the target cells. In the skin, it is well known that prostanoids are abundantly produced and that the prostanoid receptors are highly expressed. However, the physiological role of prostanoids in the skin has not been clarified. Recent developments in the molecular biology of the prostanoid receptors have enabled the investigation of the physiological roles of each receptor by disruption of the respective genes in combination with prostanoid receptor selective compounds. Here, we review novel findings relating to the roles of prostanoids in the cutaneous immune responses. These may prove useful in the development of new therapeutic agents that can selectively manipulate the actions mediated by each receptor.
Related Concept Videos
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Inflammation
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Allergic Drug Reactions
Antigen Processing Pathways
MHC Class I: Presenting Endogenous...