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Updated: Aug 24, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
Published on: October 7, 2016
Synthesis, self-assembly and characterization of a new glucoside-type hydrogel having a Schiff base on the aglycon
Chunyan Bao1, Ran Lu, Ming Jin
1College of Chemistry, Department of Organic Chemistry, Jilin University, 119 Jiefang Road, Changchun 130023, PR China.
Abstract:
A new hydrogel based on a substituted phenyl glucoside with a Schiff base in the aglycon was synthesized, and the self-assembling characteristics was studied. FTIR spectra, UV-vis absorption spectra and X-ray diffraction (XRD) revealed that pi-pi interactions between the Schiff base moieties, hydrogen bonds, and the interdigitated interactions between hydrophobic chains had effects on the formation of the self-assembling hydrogel. Scanning electron microscopic (SEM) and transmission electron microscopic (TEM) observation showed that the three-dimensional hydrogel network was constructed from nanotubes with inner diameters of ca. 75 nm and wall of ca. 20 nm.
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