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Receptor-dependent coronavirus infection of dendritic cells

Brian C Turner1, Erin M Hemmila, Nicole Beauchemin

  • 1Department of Microbiology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA.

Journal of Virology
|April 29, 2004
PubMed

Insights

Murine coronavirus infection affects immune responses. Dendritic cells (DCs) play a role in this modulation, with infection occurring via a receptor-dependent pathway involving murine CEACAM1a.

Area of Science:

  • Immunology
  • Virology
  • Cell Biology

Background:

  • Coronaviruses can alter host immune responses in mammals, including humans.
  • Dendritic cells (DCs) are critical immune cells involved in initiating and regulating adaptive immunity.
  • Understanding viral interactions with DCs is crucial for comprehending pathogenesis.

Purpose of the Study:

  • To investigate the role of dendritic cells (DCs) in murine coronavirus infection.
  • To determine if DCs are susceptible to murine coronavirus infection.
  • To elucidate the mechanism of DC infection by murine coronavirus.

Main Methods:

  • Utilized the JAW SII DC cell line for infection studies.
  • Employed primary dendritic cells from BALB/c mice and p/p mice.
  • Assessed viral susceptibility and receptor dependence, focusing on murine CEACAM1a expression.

Main Results:

  • Dendritic cells (DC) are susceptible to murine coronavirus infection.
  • Infection of DCs occurs through a receptor-dependent pathway.
  • Reduced expression of the murine coronavirus receptor, murine CEACAM1a, impacts DC susceptibility.

Conclusions:

  • Dendritic cells (DCs) are implicated in the immune modulation and pathogenesis of murine coronavirus infection.
  • Murine coronavirus utilizes a receptor-dependent pathway, involving murine CEACAM1a, to infect DCs.
  • These findings highlight DCs as key players in the host response to coronavirus.

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