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Gene expression profiling: from microarrays to medicine
Ashani T Weeraratna1, James E Nagel, Valeria de Mello-Coelho
1Clinical Immunology Section, Laboratory of Immunology, Gerontology Research Center, National Institute on Aging, Nathan Shock Dr, Baltimore, Maryland, USA.
Journal of Clinical Immunology
|April 29, 2004
Summary
Microarray analysis allows simultaneous gene assaying for disease research. Advances in data analysis and standardization are enabling its application in clinical medicine and ongoing clinical trials.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- Human genome mapping facilitates identification of disease-related genes and pathways.
- Microarray analysis enables high-throughput gene expression profiling.
- Integrating genomic data into clinical practice is a key challenge.
Purpose of the Study:
- To review the microarray technique.
- To detail clinical studies utilizing microarray analysis.
- To explore the application of gene expression profiling in medicine.
Main Methods:
- Outline of the microarray technology.
- Description of studies incorporating microarrays.
- Review of data analysis and standardization advancements.
Main Results:
- Microarray technology allows simultaneous assaying of thousands of genes.
- Recent advances facilitate the clinical application of microarrays.
- Several clinical trials are actively incorporating microarrays.
Conclusions:
- Microarray analysis is a powerful tool for disease gene discovery.
- Standardization and data analysis are crucial for clinical translation.
- The integration of microarrays into clinical trials signifies progress towards personalized medicine.