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Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by
G Finkenzeller1, D Marmé, H A Weich
1Institute of Molecular Cell Biology, University of Freiburg, Germany.
Cancer Research
|September 1, 1992
Abstract:
Platelet-derived growth factor and phorbol ester cause an increase in vascular endothelial growth factor (VEGF) mRNA expression in control NIH 3T3 fibroblasts and NIH 3T3 fibroblasts overexpressing human protein kinase C (PKC) alpha. In the case of phorbol ester-induced VEGF expression, the VEGF mRNA levels were significantly higher in cells overexpressing human PKC alpha as compared to control cells. In cells stimulated with platelet-derived growth factor or phorbol ester, induction of expression was lost after down-regulation of PKC. This indicates that PKC is involved in the signal transduction leading to VEGF expression.