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[Rosacea as a multisystemic disease]
Zorana Djaković1, Svetislav Milenković, Predrag Pesko
1Institute of Dermatovenereology, Clinical Centre of Serbia, Belgrade.
Srpski Arhiv Za Celokupno Lekarstvo
|April 30, 2004
Summary
Rosacea is a chronic inflammatory skin condition affecting the face and chest. Treatment with metronidazole shows benefit for skin, eye, and digestive symptoms, suggesting a multidisciplinary approach is needed.
Area of Science:
- Dermatology
- Ophthalmology
- Gastroenterology
Context:
- Rosacea is a chronic inflammatory skin condition impacting the face and chest, primarily in adults aged 30-60.
- Characterized by erythema, telangiectasias, flushing, papules, pustules, and swelling.
- Ocular manifestations, including blepharoconjunctivitis and dry eyes, affect a significant portion of patients, with rosacea keratitis posing a risk of blindness.
Purpose:
- To explore the association between rosacea and Helicobacter pylori infection.
- To highlight the gastrointestinal and ocular comorbidities of rosacea.
- To discuss the therapeutic benefits of metronidazole across rosacea manifestations.
Summary:
- A higher prevalence of indigestion and Helicobacter pylori infection is reported in rosacea patients compared to controls, though a causal link remains unestablished.
- Oral metronidazole demonstrates efficacy in managing the skin, ocular, and digestive symptoms associated with rosacea.
- The findings underscore the need for a multidisciplinary approach in managing this complex condition.
Impact:
- This research emphasizes the systemic nature of rosacea, extending beyond the skin to affect ocular and gastrointestinal health.
- It advocates for integrated patient care involving dermatology, ophthalmology, and gastroenterology specialists.
- Identifying potential therapeutic targets and management strategies for rosacea and its associated conditions.