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Breakthrough neurological manifestation during appropriate antituberculous therapy of miliary tuberculosis
Rangsima Lolekha1, Kulkanya Chokephaibulkit, Nirun Vanprapar
1Infectious Disease Unit, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. rangsima_l@yahoo.com
Abstract:
We report a 20-month-old girl with miliary pulmonary tuberculosis and normal neurological findings. While on treatment with isoniazid, rifampicin, pyrazinamide, and ethambutol for 1 month, she developed weakness of the lower extremities without meningism or altered consciousness. A computerized tomogram revealed tuberculomas and basal arachnoiditis. The cerebrospinal fluid findings were compatible with tuberculous meningitis. She responded well to systemic corticosteroids.
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