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Amiodarone and optic neuropathy.

M F Domingues1, H Barros, F M Falcão-Reis

  • 1Ophthalmology Department, Hospital São João, University of Porto Medical School, Porto, Portugal. mfdomingues@netcabo.pt

Acta Ophthalmologica Scandinavica
|April 30, 2004
PubMed
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Long-term amiodarone treatment significantly alters visual evoked potentials (VEP), prolonging latency and reducing amplitude. These vision changes in amiodarone patients warrant further investigation for effective screening methods.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Pharmacology

Background:

  • Amiodarone is a widely used antiarrhythmic drug.
  • Long-term amiodarone use is associated with potential ocular side effects.
  • Visual evoked potentials (VEP) can assess optic nerve and visual pathway function.

Purpose of the Study:

  • To evaluate clinical, perimetric, contrast sensitivity, and VEP findings in patients undergoing long-term amiodarone therapy.
  • To compare these findings with age-matched control subjects.

Main Methods:

  • 14 patients on chronic amiodarone and 14 controls underwent ophthalmological exams.
  • Evaluations included Goldmann perimetry, Humphrey visual field testing, contrast sensitivity (CCS), and pattern VEP.
  • Data collected at baseline and 1-year follow-up.

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Main Results:

  • Patients showed significantly prolonged pattern VEP latency (L-VEP) and reduced amplitude (a-VEP) compared to controls.
  • A 1-year follow-up revealed an average L-VEP increase of 1.96 ms and a-VEP decrease of 0.69 µV.
  • Abnormal tritan CCS results were found in 68% of eyes; higher amiodarone doses correlated with more pronounced VEP changes.

Conclusions:

  • Long-term amiodarone treatment leads to significant alterations in pattern VEP (prolonged latency, reduced amplitude).
  • Current data are insufficient to establish definitive visual screening recommendations for amiodarone patients.