Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Shared and private variability in the auditory cortex.

Michael R Deweese1, Anthony M Zador

  • 1Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Journal of Neurophysiology
|April 30, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Specific expansion of motor cortical projections in a singing mouse.

Nature·2026
Same author

Synaptic connectomics by sequencing.

Nature methods·2026
Same author

A lineage-based model of scalable positional information in vertebrate brain development.

Neuron·2026
Same author

Evolution and Development of Neural Circuits.

Cold Spring Harbor perspectives in biology·2025
Same author

Discovery and shaping of decision strategies using adversarial stimuli in rats.

bioRxiv : the preprint server for biology·2025
Same author

Selective expansion of motor cortical projections in the evolution of vocal novelty.

bioRxiv : the preprint server for biology·2024

Neural circuits in the auditory cortex minimize response variability. Researchers found that private neural noise is small, suggesting efficient signal processing despite potential noise accumulation.

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Computational Neuroscience

Background:

  • Cortical sensory response variability is often considered a computational constraint.
  • The auditory cortex, however, exhibits surprisingly low response variability.

Purpose of the Study:

  • To investigate the sources of trial-to-trial variability in subthreshold membrane potential fluctuations in the auditory cortex.
  • To differentiate between private and shared sources of variability in tone-evoked responses.

Main Methods:

  • In vivo whole-cell patch-clamp recordings in anesthetized rats.
  • Analysis of subthreshold membrane potential fluctuations during tone-evoked responses.
  • Application of quantal analysis methods to partition response variability.

Related Experiment Videos

Main Results:

  • The private component of subthreshold variability was found to be small (1-3 mV).
  • The shared component, arising from network interactions, was larger and more heterogeneous (0-10 mV).
  • Low private variability was observed even after several synaptic relays from the auditory periphery.

Conclusions:

  • The auditory cortex exhibits remarkably low private response variability.
  • Neural circuitry may be organized to suppress the accumulation of private noise during signal propagation.
  • This efficient noise control could be crucial for accurate auditory processing.