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Related Experiment Videos

Involvement of monkey inferior colliculus in spatial hearing.

Marcel P Zwiers1, Huib Versnel, A John Van Opstal

  • 1Department of Medical Physics and Biophysics, University of Nijmegen, 6525 EZ Nijmegen, The Netherlands.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|April 30, 2004
PubMed
Summary

The midbrain inferior colliculus (IC) broadly encodes sound location and intensity in primates. This neural activity, modulated by eye position, aids in rapid sound localization for orienting movements.

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Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Primate Sensory Processing

Background:

  • The inferior colliculus (IC) in the midbrain is crucial for auditory processing, particularly sound localization.
  • Limited evidence exists on IC neuronal responses in behaving primates for two-dimensional (2D) sound coding.

Purpose of the Study:

  • To investigate single-unit responses in the primate IC to systematically varied sound locations and levels.
  • To explore the influence of eye position on auditory responses within the IC.
  • To model how IC population activity could contribute to sound localization and sensorimotor transformations.

Main Methods:

  • Recorded single-unit activity in the IC of monkeys while presenting broadband sounds with controlled 2D locations and sound levels.
  • Monkeys maintained fixation on visual targets during auditory stimulation.

Related Experiment Videos

  • Investigated auditory response modulation by eye position by varying visual target locations.

    • Main Results:

    • IC neurons exhibited broad tuning to sound azimuth and level, often described by multiplicative, planar modulation.
    • Some neurons showed varied responses to sound elevation, with specific or monotonic tuning.
    • A subset of IC cells displayed weak but systematic modulation of auditory responses by 2D eye position, suggesting multiplicative interactions.

    Conclusions:

    • Primate IC neurons encode 2D sound location and intensity through broadly tuned, multiplicatively modulated responses.
    • Eye position modulates auditory responses in the IC, potentially integrating auditory and visual-motor information.
    • IC population activity may facilitate the transformation of head-centered sound location into eye-centered representations for orienting behaviors.