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Subclinical vitamin A deficiency in Israeli-Bedouin toddlers
C L Coles1, A Levy, R Gorodischer
1S Daniel Abraham International Center for Health and Nutrition, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Insights
Subclinical vitamin A deficiency affects over 15% of Bedouin children, with male sex and stunting as key risk factors. Interventions should focus on dietary intake and maternal education to prevent this deficiency.
Area of Science:
- Pediatrics
- Nutritional Science
- Public Health
Background:
- Subclinical vitamin A deficiency poses a significant health concern in developing populations.
- Early identification and intervention are crucial for child development and preventing long-term health issues.
Purpose of the Study:
- To estimate the prevalence of subclinical vitamin A deficiency in Arab-Bedouin children at 18 months of age.
- To identify risk factors associated with vitamin A deficiency in this population.
Main Methods:
- A community-based, prospective cohort study was conducted with 117 healthy Bedouin infants recruited at birth.
- Serum retinol concentrations were measured at 18 months to assess vitamin A status.
- Risk factors including sex, nutritional stunting, season, and maternal education were analyzed.
Main Results:
- Over 15% of children exhibited serum retinol levels below 0.7 micromol/l, indicating vitamin A deficiency.
- Male sex, stunting at 12 months, and the warm season were significantly associated with deficiency.
- Higher maternal education was linked to a reduced risk of vitamin A deficiency.
Conclusions:
- A significant vitamin A deficiency problem exists among Bedouin children.
- Preventive strategies should include enhancing dietary vitamin A intake, particularly during warmer months.
- Controlling diarrheal diseases to prevent stunting and providing nutritional education to women are recommended interventions.
Objective:
This study was designed to estimate the prevalence of and evaluate risk factors for subclinical vitamin A deficiency in Arab-Bedouin children at age 18 months, followed from birth.
Design:
Community-based, prospective, cohort study conducted in Rahat, a large Arab-Bedouin township, located near the city of Beer Sheva in the Negev region of southern Israel.
Subjects:
Healthy Bedouin infants (n=117) from the township, born at Soroka University Medical Center (SUMC) in Beer Sheva, were randomly recruited at birth. Enrollment was restricted to well infants born weighing >2500 g at birth.
Results:
More than 15% of the children had serum retinol concentrations below 0.7 micromol/l. Male sex (odds ratio (OR) 4.17 [1.14-15.32], P=0.031), stunting at age 12 months (OR 10.09 [2.00-50.97], P=0.05) and warm season at age 18 months (OR 6.20 [1.36-28.28], P=0.018) were associated with vitamin A deficiency. Maternal education decreased the risk of vitamin A deficiency (OR 0.81 [0.68-0.95], P=0.011).
Conclusions:
Study results indicate a significant vitamin A deficiency problem among Bedouin children. Deficiency may be prevented by increasing dietary intake of vitamin A, especially during the warm season. Other interventions include preventing and controlling diarrheal diseases in order to avert nutritional stunting, and providing nutritional education to women of childbearing age.
Sponsorship:
This study received financial support from the National Institute of Allergy and Infectious Diseases (AI-26497), the US-Israel Bi-national Science Foundation (BSF 90-00257), and the National Academy of Sciences/Institute of Medicine (AID/ANE 0158-G-SS-9035-00).
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