Related Experiment Video

Updated: Aug 24, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Novel combinations using pemetrexed in malignant mesothelioma

Shirish M Gadgeel1, Harvey I Pass

  • 1Wayne State University/Karmanos Cancer Institute, Detroit, MI 48201, USA. gadgeels@karmanos.org

Clinical Lung Cancer
|May 1, 2004
PubMed

Insights

Pemetrexed shows therapeutic benefits for malignant mesothelioma patients, offering a promising chemotherapy option. Further research explores novel pemetrexed combinations for improved treatment outcomes.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Malignant mesothelioma is a rare, aggressive cancer with limited treatment options.
  • Most patients cannot undergo curative surgery, and chemotherapy offers modest efficacy.

Purpose of the Study:

  • To review the therapeutic benefits of pemetrexed in malignant mesothelioma.
  • To discuss potential future pemetrexed-based combination therapies.

Main Methods:

  • Review of existing clinical data on pemetrexed (single-agent and combination therapy).
  • Analysis of therapeutic outcomes in malignant mesothelioma patients.

Main Results:

  • Pemetrexed demonstrates therapeutic benefits as a single agent and in combination with cisplatin.
  • Current data suggests pemetrexed is an effective treatment for malignant mesothelioma.

Conclusions:

  • Pemetrexed offers a valuable therapeutic option for malignant mesothelioma.
  • Novel pemetrexed combinations warrant further investigation for enhanced treatment strategies.

More Related Videos

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...