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Cerebral perfusion CT: technique and clinical applications
Ellen G Hoeffner1, Ian Case, Rajan Jain
1Departments of Radiology and Neurosurgery, University of Michigan Health System, 1500 E Medical Center Drive, University Hospital B2 A209, Ann Arbor, MI 48109, USA. hoeffner@umich.edu
Radiology
|May 1, 2004
Summary
Perfusion CT offers rapid brain blood flow analysis, aiding in diagnosing stroke and evaluating conditions like vasospasm. Despite some debate, its clinical utility in assessing cerebrovascular reserve and neoplasms is significant.
Area of Science:
- Neuroradiology
- Medical Imaging
Background:
- Perfusion computed tomography (CT) is an advanced imaging technique.
- It provides qualitative and quantitative assessment of cerebral perfusion.
Purpose of the Study:
- To review the technique, clinical applications, and controversies of perfusion CT.
- To highlight its role in diagnosing and managing cerebrovascular diseases.
Main Methods:
- Utilizes central volume principle (CBF = CBV/MTT) with deconvolution algorithms.
- Generates maps of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT).
Main Results:
- Useful for noninvasive diagnosis of cerebral ischemia and infarction.
- Effective in evaluating vasospasm, cerebrovascular reserve, and microvascular permeability.
Conclusions:
- Perfusion CT is a valuable tool in neuroradiology despite existing controversies.
- Its applications range from acute stroke assessment to pre-surgical planning.