Effect of aging on contractile response to KCl, norepinephrine and 5-hydroxytryptamine in isolated human basilar artery
Related Experiment Videos
K Hatake1, I Wakabayashi, E Kakishita
1Department of Legal Medicine, Hyogo College of Medicine, Japan.
General Pharmacology
|May 1, 1992
Abstract:
1. We investigated the effect of aging on contractile response in human basilar artery. 2. The maximal contraction caused by KCl, norepinephrine and 5-hydroxytryptamine decreased with age. 3. ED50 value for norepinephrine or 5-hydroxytryptamine did not correlate with age. 4. These results suggest that the decrease in contractile response is due to nonspecific changes in the medial structure of the artery.