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Related Experiment Videos

Activated protein C and ischemic stroke.

John H Griffin1, José A Fernández, Dong Liu

  • 1Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.

Critical Care Medicine
|May 1, 2004
PubMed
Summary
This summary is machine-generated.

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Activated protein C (APC) shows promise in treating ischemic stroke by reducing inflammation and protecting brain cells. Studies indicate APC

Area of Science:

  • Neuroscience and Pharmacology
  • Biochemistry and Molecular Biology

Background:

  • The protein C system, including activated protein C (APC), plays a role in various physiological processes.
  • Ischemic stroke is a significant cause of mortality and morbidity, necessitating novel therapeutic strategies.
  • Understanding the multifaceted roles of APC beyond anticoagulation is crucial for therapeutic development.

Purpose of the Study:

  • To review and synthesize current knowledge on the protein C system, particularly activated protein C (APC), in the context of ischemic stroke.
  • To explore the neuroprotective, anti-inflammatory, and anti-apoptotic mechanisms of APC.
  • To evaluate the therapeutic potential of APC for ischemic stroke based on clinical, animal, and in vitro evidence.

Main Methods:

  • A narrative review of published literature from MEDLINE (2000-2003) was conducted.

Related Experiment Videos

  • The review encompassed clinical observations, animal model experimentation, and in vitro studies.
  • Focus was placed on studies investigating the protein C system and its role in ischemic stroke.

    • Main Results:

    • Low plasma APC levels and poor APC response may indicate stroke risk.
    • APC demonstrates significant anti-inflammatory and neuroprotective effects in murine ischemic stroke models.
    • APC's neuroprotection is mediated by protease-activated receptor-1 and endothelial protein C receptor, independent of its anticoagulant activity, by inhibiting apoptosis and inflammation.

    Conclusions:

    • Activated protein C (APC) exhibits potent neuroprotective and anti-inflammatory properties relevant to ischemic stroke.
    • The anti-apoptotic and gene-modulating effects of APC, mediated via specific receptors, are key to its therapeutic potential.
    • Ischemic stroke represents a promising therapeutic target for treatment with APC.