Related Experiment Video
Updated: Aug 10, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
[Factors influencing secondary preventive blood pressure control in hypertensive stroke patients]
K Spengos1, G Tsivgoulis, E Manios
1Neurologische Klinik, Eginition Krankenhaus, Universität Athen, Athen, Griechenland. spengos@hol.gr
Insights
Blood pressure control is poor in stroke survivors, with only 38.8% achieving target levels. Diabetes negatively impacts control, while heart disease and diuretic use improve it, highlighting the need for tailored antihypertensive strategies.
Area of Science:
- Cardiology
- Neurology
- Pharmacology
Background:
- Hypertension management post-stroke remains a significant challenge, with over half of survivors exhibiting uncontrolled blood pressure (BP) despite medication.
- Limited data exists on the factors contributing to suboptimal BP control in this patient population.
Purpose of the Study:
- To prospectively investigate parameters influencing the effectiveness of BP control in hypertensive patients following a cerebrovascular event.
- To identify predictors of successful antihypertensive treatment in stroke survivors.
Main Methods:
- Prospective evaluation of hypertensive stroke survivors.
- Assessment of factors affecting blood pressure control effectiveness during follow-up.
Main Results:
- Effective BP control was achieved in only 38.8% of patients at 3 months post-stroke.
- Diabetes mellitus was associated with reduced BP reduction, whereas coronary artery disease correlated with improved control.
- Diuretic use emerged as an independent positive predictor of effective BP control; combined therapy was superior to monotherapy.
Conclusions:
- Stroke survivors demonstrate suboptimal arterial pressure control.
- Risk factors, co-existing heart disease, and specific antihypertensive medications significantly influence the prognosis for effective BP management.
Background:
More than half of patients with documented hypertension surviving cerebrovascular events do not have their blood pressure (BP) controlled, despite the use of antihypertensive medication. Data on the possible reasons for poor BP control in stroke survivors are limited.
Methods:
We evaluated prospectively parameters influencing the effectiveness of BP control in hypertensive stroke survivors who were followed up.
Results:
At 3 months after stroke BP was effectively controlled in only 38.8% of patients. Diabetes mellitus had a negative influence on the effectiveness of antihypertensive medication by reducing significantly the chance of achieving a significant BP reduction, while patients suffering from coronary artery disease had an increased chance of getting their BP under control within 3 months after stroke onset. Diuretic medication was found to be an independent positive predictor for effective antihypertensive control. Combined therapy including diuretics was significantly more effective than antihypertensive monotherapy.
Conclusions:
Arterial pressure control in stroke survivors is poor. Risk factor profile, manifest heart disease, and the chosen antihypertensive medication are factors of prognostic relevance for effective BP control.
Related Concept Videos
Factors affecting Blood pressure
Physiological Factors:
Hypertension and Regulation of Blood Pressure
Hypertension I: Introduction
Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension IV: Drug Therapy and Lifestyle Modifications
Hypertension V: Nursing Management

