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Updated: Jul 31, 2026
10:37
Combined Nucleotide and Protein Extractions in Caenorhabditis elegans
Published on: March 17, 2019
Sequence of a cDNA clone encoding a rat Reg-2 protein.
T Kamimura1, C West, E Beutler
1Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037.
Gene
|September 10, 1992
Summary
Researchers identified a rat cDNA clone encoding the Reg-2 protein, which is homologous to the regenerating (Reg) protein. This discovery advances understanding of Reg protein family evolution and function.
Area of Science:
- Molecular Biology
- Genetics
- Protein Science
Background:
- The regenerating (Reg) protein family plays roles in tissue regeneration and cell proliferation.
- Understanding the diversity of Reg proteins across species is crucial for elucidating their functions.
Purpose of the Study:
- To report the nucleotide sequence of a rat cDNA clone encoding a novel protein homologous to Reg proteins.
- To characterize the newly identified rat protein, designated Reg-2.
Main Methods:
- Nucleotide sequencing of a rat cDNA clone.
- Bioinformatic analysis to compare amino acid sequences with known Reg proteins.
Main Results:
- A rat cDNA clone encoding a protein homologous to the Reg protein was identified and sequenced.
- The encoded protein, Reg-2, exhibits significant amino acid sequence similarity to rat (60%), bovine (78%), and human (61%) Reg proteins.
Conclusions:
- The identification of rat Reg-2 expands the known Reg protein family.
- The sequence homology suggests conserved functions of Reg proteins across mammalian species, particularly between rat, bovine, and human orthologs.
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