Related Experiment Videos
Limited genetic diversity in polynesians reflected in the highly polymorphic 3'HVR alpha-globin gene marker
M S Hertzberg1, K N Mickleson, R J Trent
1Department of Molecular Genetics, Royal Prince Alfred Hospital, Camperdown, N.S.W., Australia.
Human Heredity
|January 1, 1992
Abstract:
Polynesians from five distinct island groups were studied with DNA probe alpha 3'HVR, a highly polymorphic VNTR (variable number of tandem repeats) minisatellite region associated with the alpha-globin gene cluster. Results showed a paucity of genetic heterozygosity together with clustering of alpha 3'HVR alleles with alpha-globin DNA haplotypes and alpha-globin gene rearrangements. This restricted diversity is consistent with population bottlenecks in the colonization of Polynesia.