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Genetic markers in alcoholic liver cirrhosis
M V Lareu1, A Alvarez-Prechous, C Pardiñas
1Institute of Legal Medicine, University of Santiago de Compostela, Spain.
Human Heredity
|January 1, 1992
Abstract:
11 genetic markers were typed in 157 individuals suffering from alcoholic cirrhosis, and compared with a random sample of healthy individuals. No significant differences were found for transferrin, specific group component, orosomucoid, esterase D, phosphogluconate dehydrogenase and adenylate kinase. Strong associations between alcoholic cirrhosis and alpha-1-antitrypsin PI*Z allele, haptoglobin HP*1 allele and acid phosphatase ACP AC phenotype were observed. The biological significance of these associations and their relationships with the development of alcoholic cirrhosis are also discussed.