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Related Experiment Videos

[Current data on granulocytes donations].

D Lemau de Talancé1, D Benomar, C Boulat

  • 1Site Lecourbe, EFS-Ile-de-France, 20, rue Lecourbe 75015 Paris, France.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|May 4, 2004
PubMed
Summary
This summary is machine-generated.

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Management of the blood supply for a Jk(a-b-) patient with an anti-Jk3 in preparation for an urgent heart transplant: An illustrative example of a successful international cooperation.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2018
Same author

Vox Sanguinis International Forum on provision of granulocytes for transfusion and their clinical use: summary.

Vox sanguinis·2017
Same author

Vox Sanguinis International Forum on provision of granulocytes for transfusion and their clinical use.

Vox sanguinis·2017
Same author

[Pediatric preparations of blood products].

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2017
Same author

Lymphodepletion followed by infusion of suicide gene-transduced donor lymphocytes to safely enhance their antitumor effect: a phase I/II study.

Leukemia·2014
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[How to handle unexpected biological abnormalities observed in the pre-donation workup for hematopoietic stem cell transplantation: an SFGM-TC report on pre-transplant cytomegalovirus, Epstein-Barr virus, Toxoplasma gondii, or syphilis IgM positive serology test].

Pathologie-biologie·2013

Granulocyte transfusions are vital for patients with severe infections, including aplastic anemia and fungal diseases. Careful donor-recipient matching and optimized collection methods ensure effective granulocyte therapy for both children and adults.

Area of Science:

  • Hematology
  • Transfusion Medicine

Context:

  • Granulocyte transfusions are critical for immunocompromised patients facing severe infections.
  • Conditions like aplastic anemia, septic granulomatosis, and visceral aspergillosis necessitate granulocyte support.
  • Standard transfusion protocols require careful consideration of donor-recipient compatibility.

Purpose:

  • To outline the essential parameters and procedures for effective granulocyte collection and transfusion.
  • To detail the necessary compatibility checks and preparatory steps for granulocyte therapy.
  • To describe the methodology for optimizing granulocyte yield for clinical use.

Summary:

  • Donor-recipient compatibility (ABO, D, Kell, cytomegalovirus) is crucial for successful granulocyte transfusion.
  • Pre-treatment with dexamethasone followed by G-CSF stimulates white blood cell production for collection.

Related Experiment Videos

  • Hydroxyethylstarch sedimentation is employed for efficient granulocyte separation, with typical yields between 2-4 x 10^10 white cells.

    • Impact:

    • Enables effective granulocyte transfusion in pediatric and adult patients with life-threatening infections.
    • Highlights the importance of precise heparin dosing for donor safety during apheresis.
    • Establishes a framework for optimizing granulocyte collection efficiency and therapeutic efficacy.