Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in particle-induced osteolysis in obese (ob/ob) mice.

M von Knoch1, D E Jewison, J D Sibonga

  • 1Department of Orthopaedics, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA. mariusvonknochh@yahoo.com

Biomaterials
|May 4, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of spaceflight countermeasures on trabecular bone score (TBS) of the lumbar spine.

Archives of osteoporosis·2026
Same author

AOA Critical Issues Symposium: Leadership and Education During and After COVID-19: Back to the Future or a New Normal.

The Journal of bone and joint surgery. American volume·2023
Same author

Corrigenda.

The bone & joint journal·2020
Same author

Hip load capacity and yield load in men and women of all ages.

Bone·2020
Same author

Prior hip or knee prosthetic joint infection in another joint increases risk three-fold of prosthetic joint infection after primary total knee arthroplasty: a matched control study.

The bone & joint journal·2019
Same author

2019 John Charnley Award: Increased risk of prosthetic joint infection following primary total knee and hip arthroplasty with the use of alternative antibiotics to cefazolin: the value of allergy testing for antibiotic prophylaxis.

The bone & joint journal·2019
Same journal

Corrigendum to "Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib" [Biomaterials 2020, 240, 119845].

Biomaterials·2026
Same journal

Mg-integrated octopus-inspired hydrogel dressing enables autonomous adhesion and wound closure for enhanced healing via sequential microenvironment regulation.

Biomaterials·2026
Same journal

Engineering miRNA-223 nanocomplexes via bioorthogonal self-assembly for precision therapy of intervertebral disc degeneration.

Biomaterials·2026
Same journal

Corrigendum to "Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide" [Biomaterials 42 (2015) 16442].

Biomaterials·2026
Same journal

An injectable Ce-MnCo LDH nanozyme gel with cascade catalytic activity for acute radiation proctitis in rats.

Biomaterials·2026
Same journal

Peptide coacervate-mediated siRNA delivery for dual PD-1/PD-L1 blockade to enhance colorectal cancer immunotherapy.

Biomaterials·2026
See all related articles

Genetically determined obesity in mice reduced osteolysis caused by polyethylene particles. This suggests obesity may protect against particle-induced bone resorption, potentially impacting clinical risk assessments for osteolysis.

Area of Science:

  • Orthopedics
  • Immunology
  • Genetics

Background:

  • Osteolysis, or bone loss, from wear debris can vary between individuals.
  • Genetic predisposition for heightened osteolytic responses to wear debris is not fully understood.

Purpose of the Study:

  • To investigate if genetically determined obesity influences the bone's response to particulate debris.
  • To assess the impact of obesity on particle-induced osteolysis in a mouse model.

Main Methods:

  • Polyethylene particles were implanted onto the calvaria of wild-type and obese (ob/ob) mice.
  • Calvaria were harvested after 7 days and analyzed using histomorphometry, including toluidine blue and tartrate-resistant alkaline phosphatase staining.

Main Results:

Related Experiment Videos

  • Obese mice showed significantly fewer osteoclasts (2.857/mm) compared to wild-type mice (8.000/mm) when exposed to particles (p=0.002).
  • Bone resorption was also reduced in obese mice (1.265/mm²) versus wild-type mice (1.895/mm²) (p=0.0438).

Conclusions:

  • Genetically determined obesity diminished the osteolytic response to particulate debris in mice.
  • Obesity may confer a protective effect against particle-induced bone resorption, similar to its association with osteoporosis.