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Updated: Aug 24, 2026

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
Published on: September 2, 2020
Sensitization of recombinant vanilloid receptor-1 by various neurotrophic factors
József Lázár1, Tamás Szabó, Rita Marincsák
1Department of Physiology and Cell Physiology Research Group of the Hungarian Academy of Sciences, H-4012 Debrecen, Nagyerdei krt. 98. PO Box 22, Hungary.
Abstract:
The vanilloid receptor (VR1) is a central integrator molecule of nociceptive stimuli. In this study, we have measured the effects of various neurotrophins (nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and -4) on recombinant rat VR1-mediated intracellular calcium rise in response to capsaicin in VR1/C6 cells. Our results clearly show that all neurotrophins sensitize the VR1 to capsaicin. Furthermore, using K252a, an inhibitor of tyrosine kinases, we present that actions of neurotrophins are mediated by the trk (A, B, C) receptors expressed in these cells. These data argue for the putative roles of neurotrophins in inducing inflammatory (thermal) hyperalgesia via VR1.
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