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Benefits of obstructive sleep apnoea treatment in coronary artery disease: a long-term follow-up study

Olivier Milleron1, Rémy Pillière, Arlette Foucher

  • 1Division of Cardiology, Ambroise Paré Teaching Hospital, AP-HP, UFR Paris-Ile de France-Ouest, Université de Versailles-Saint Quentin en Yvelines, 92104 Boulogne, France. olivier.milleron@apr.ap-hop-paris.fr

European Heart Journal
|May 4, 2004
PubMed

Insights

Treating obstructive sleep apnoea (OSA) in patients with coronary artery disease (CAD) significantly reduces cardiovascular events. This intervention lowers the risk and delays the occurrence of major adverse cardiac events in this high-risk population.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Internal Medicine

Background:

  • Obstructive sleep apnoea (OSA) is prevalent in patients with coronary artery disease (CAD).
  • The impact of OSA treatment on cardiovascular outcomes in CAD patients remains an area of investigation.

Purpose of the Study:

  • To evaluate the long-term effect of treating OSA on the incidence of cardiovascular events in patients with established CAD.

Main Methods:

  • A prospective study of 54 patients with both CAD and OSA.
  • Patients were divided into two groups: those who received OSA treatment (CPAP or surgery) and those who declined treatment.
  • Follow-up averaged 86.5 months, assessing a composite endpoint of cardiovascular death, acute coronary syndrome, heart failure hospitalization, or revascularization.

Main Results:

  • The OSA treatment group (n=25) experienced significantly fewer composite endpoint events (24%) compared to the untreated group (n=29, 58%) (P<0.01).
  • OSA treatment demonstrated a significant reduction in the risk of composite endpoint occurrence (HR 0.24; 95% CI, 0.09-0.62; P<0.01).
  • The benefits extended to a reduction in the risk of individual components of the composite endpoint.

Conclusions:

  • Treatment of OSA in patients with CAD is associated with a significant decrease in new cardiovascular events.
  • Intervention for OSA delays the time to the occurrence of major adverse cardiovascular events in this patient cohort.
Abstract

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