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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Hospitalisations for gastroenteritis: the role of rotavirus
Paul Rivest1, Mélanie Proulx, Guy Lonergan
1Direction de santé publique de Montréal-Centre, 1301 rue Sherbrooke Est, Montréal, Qué., Canada H2L 1M3. privest@santepub-mtl.qc.ca
Insights
Rotavirus is the primary cause of gastroenteritis hospitalizations in young children during winter and spring in Quebec. This study found rotavirus in over 70% of tested pediatric gastroenteritis cases.
Area of Science:
- Pediatric infectious diseases
- Virology
- Public health surveillance
Background:
- Gastroenteritis is a common cause of childhood hospitalization.
- Rotavirus is a significant pathogen responsible for severe gastroenteritis in infants and young children.
- Understanding the burden of rotavirus is crucial for public health interventions.
Purpose of the Study:
- To determine the proportion of hospitalizations for gastroenteritis in children under five attributable to rotavirus.
- To analyze the clinical presentation and outcomes of rotavirus gastroenteritis in hospitalized children.
- To assess the seasonal trends of rotavirus activity.
Main Methods:
- Prospective study conducted in seven hospitals in Quebec from December 1999 to May 2000.
- Stool samples were collected from children under five hospitalized for gastroenteritis.
- Samples were tested for the presence of rotavirus.
Main Results:
- Of 944 children hospitalized for gastroenteritis, 565 were tested for rotavirus, and 405 (71.7%) tested positive.
- The proportion of positive rotavirus tests increased from 51.6% in December to 78.1% in April.
- Children with rotavirus gastroenteritis were more likely to present with vomiting and require IV fluids but had shorter hospital stays compared to those with non-rotavirus gastroenteritis.
Conclusions:
- Rotavirus is responsible for the vast majority of winter and spring gastroenteritis hospitalizations in young children in Quebec.
- Rotavirus infection in this age group is primarily associated with vomiting, dehydration requiring IV fluids, and shorter hospitalizations.
- These findings highlight the substantial impact of rotavirus on pediatric healthcare utilization during specific seasons.
Abstract:
To determine the proportion of hospitalisations for gastroenteritis caused by rotavirus, we tested for rotavirus stool samples of all children under the age of five hospitalised for gastroenteritis between 1 December 1999 and 30 May 2000 in seven community and specialised hospitals in Quebec. Of 944 children hospitalised, 565 (59.9%) were screened for rotavirus and 405 (71.7%) tested positive. From December to April, the proportion of positive results rose from 51.6 to 78.1%. Compared with children whose test results were negative, children who tested positive presented vomiting more frequently upon admission (88.9 versus 60.4%) and needed IV fluids in greater proportion (94.1 versus 78.0%), but spent less time in hospital (2.8 versus 3.3 days). Aside from dehydration, no complications were noted. In Quebec, a large majority of winter and spring hospitalisations for gastroenteritis in children is attributable to rotavirus.
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