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Massive subchorionic hematomas following thrombolytic therapy in pregnancy
Ihab M Usta1, Mazen Abdallah, May El-Hajj
1Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon. iu00@aub.edu.lb
Obstetrics and Gynecology
|May 4, 2004
Summary
Thrombolytic therapy for pregnant patients with thrombotic prosthetic mitral valves may cause massive subchorionic hematomas. Further research is needed to confirm these placental findings and their impact on pregnancy outcomes.
Area of Science:
- Obstetrics and Gynecology
- Cardiology
- Pharmacology
Background:
- Medical therapy for thrombotic prosthetic valves in pregnancy is an alternative to surgery, particularly for hemodynamically compromised patients.
- Placental changes following thrombolytic therapy during pregnancy are infrequently documented.
Observation:
- Two pregnant women with prosthetic mitral valve thrombosis received thrombolytic agents.
- Sonograms revealed massive subchorionic hematomas in both patients post-thrombolysis.
- One hematoma persisted, leading to cesarean delivery at 34 weeks; the other resolved, with delivery at term.
Findings:
- Massive subchorionic hematomas were observed in pregnant patients after thrombolytic therapy.
- The clinical significance and frequency of these placental findings require further investigation.
Implications:
- Subchorionic hematomas are a potential complication of thrombolytic therapy in pregnancy.
- Additional studies are necessary to ascertain the prevalence and impact of these hematomas on pregnancy outcomes.