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Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
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Dendritic cell immunotherapy: mapping the way

Carl G Figdor1, I Jolanda M de Vries, W Joost Lesterhuis

  • 1Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, PO Box 9101, 6500HB Nijmegen, The Netherlands. c.figdor@ncmls.kun.nl

Nature Medicine
|May 4, 2004
PubMed

Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system, with the potential to either stimulate or inhibit immune responses. Exploiting the immune-regulatory capacities of dendritic cells holds great promise for the treatment of cancer, autoimmune diseases and the prevention of transplant rejection. Although early clinical trials indicate that DC vaccines can induce immune responses in some cancer patients, careful study design and use of standardized clinical and immunological criteria are needed.

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