[Choroid plexus tumours: epidemiologic comparative study of 24 cases]

Area of Science:

• Neuro-oncology
• Pediatric Neurosurgery
• Central Nervous System Tumors

Background:

• Choroid plexus tumors are rare central nervous system neoplasms predominantly affecting children.
• This study focuses on a series of 38 patients with neuroectodermal tumors, specifically analyzing cases of choroid plexus carcinoma (CPC).

Purpose of the Study:

• To analyze the clinical features, treatment outcomes, and prevalence of choroid plexus carcinoma (CPC) in a pediatric patient cohort.
• To investigate the potential etiological factors contributing to the high prevalence of CPC observed in Curitiba.

Main Methods:

• Retrospective review of 38 patients with neuroectodermal tumors.
• Histological and immunohistochemical diagnosis for choroid plexus carcinoma (CPC).
• Analysis of clinical presentation, surgical treatment, and patient outcomes, including recurrence and survival rates.

Main Results:

• Twenty-four patients were diagnosed with choroid plexus carcinoma (CPC).
• The most common clinical features included hydrocephalus, intracranial hypertension, and convulsions.
• Surgical treatment resulted in 2 deaths from complications, with 9 patients experiencing recurrence and 7 remaining alive.

Conclusions:

• Choroid plexus carcinoma (CPC) shows a notable prevalence in Curitiba compared to other choroid plexus tumors.
• The high incidence may indicate a localized environmental or pathogenic factor influencing CPC development.
• Further research is warranted to identify potential pathogenic agents responsible for the increased CPC prevalence.