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Epidemiology of rotavirus diarrhoea in Iranian children

B Khalili1, L E Cuevas, N Reisi

  • 1Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

Journal of Medical Virology
|May 4, 2004
PubMed

Insights

Human rotavirus causes severe diarrhea in children globally. This study identified common rotavirus G and P types in Iran, finding they align with global strains covered by current vaccines.

Area of Science:

  • Virology
  • Pediatrics
  • Epidemiology

Background:

  • Human rotavirus is a primary cause of severe infantile diarrhea worldwide.
  • Understanding rotavirus epidemiology and genotypes is crucial for public health interventions.

Purpose of the Study:

  • To investigate the etiology of viral diarrhea and characterize rotavirus infections in children in Shahrekord, Iran.
  • To identify common rotavirus G and P genotypes circulating in the region.

Main Methods:

  • Stool samples from children under 5 were collected and screened for enteric viruses using electron microscopy (EM).
  • Rotaviruses were further characterized using enzyme-linked immunosorbent assay (ELISA), reverse transcription-polymerase chain reaction (RT-PCR), and electropherotyping.
  • RT-PCR was employed for G and P type determination.

Main Results:

  • Rotavirus was the predominant virus identified (78%), followed by coronavirus and calicivirus.
  • Rotavirus showed seasonal variation, peaking from November to February, primarily affecting children under 2 years old.
  • The most frequent genotypes were G1 (82%) and P[8] (74%), consistent with global patterns.

Conclusions:

  • This study provides the first report on rotavirus genotypes in Iranian children.
  • The identified prevalent G1, G2, P[8], and P[4] types are globally common and targeted by existing rotavirus vaccines.
  • Findings support the potential efficacy of current vaccination strategies in Iran.

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