Finding Cinderella after the ball: a three-hybrid approach to drug target identification
Scott Lefurgy1, Virginia Cornish
1Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Abstract:
A major bottleneck in drug discovery is identifying the targets of small molecules. The yeast three-hybrid assay extends the two-hybrid approach to screen for protein-small molecule interactions. In this issue of Chemistry & Biology, GPC Biotech reports the first application of this promising assay.
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