Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecular Models02:00

Molecular Models

43.8K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.8K
Molecular Shapes01:18

Molecular Shapes

62.4K
Molecules have characteristic shapes that are crucial for their function. The arrangement of various electron groups around the central atom dictates their molecular geometry. Electron pairs in the valence shell of a central atom will adopt an arrangement that minimizes repulsions between the electron pairs by maximizing the distance between them. The valence electrons form either bonding pairs, located primarily between bonded atoms, or lone pairs.
Two regions of electron density in a diatomic...
62.4K
Cohesion01:07

Cohesion

59.5K
Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
On a...
59.5K
Self-Presentation: Self-Monitoring and Self-Handicapping02:05

Self-Presentation: Self-Monitoring and Self-Handicapping

44.8K
People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
44.8K
Multiple Allele Traits01:49

Multiple Allele Traits

38.2K
The Concept of Multiple Allelism
38.2K
Basic Postulates of Kinetic Molecular Theory: Particle Size, Energy, and Collision02:43

Basic Postulates of Kinetic Molecular Theory: Particle Size, Energy, and Collision

37.9K
The ideal-gas equation, which is empirical, describes the behavior of gases by establishing relationships between their macroscopic properties. For example, Charles’ law states that volume and temperature are directly related. Gases, therefore, expand when heated at constant pressure. Although gas laws explain how the macroscopic properties change relative to one another, it does not explain the rationale behind it.
37.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-Proliferative Acyl Phenols and Arylnonanoids from the Fruit Rind of Myristica malabarica Lam.

Chemistry & biodiversity·2022
Same author

Correction to: Antimalarial Natural Products.

Progress in the chemistry of organic natural products·2022
Same author

Antimalarial Natural Products.

Progress in the chemistry of organic natural products·2022
Same author

Structure Elucidation and Confirmation of Phloroglucinols from the Roots of <i>Garcinia dauphinensis</i> by Comparison of Experimental and Calculated ECD Spectra and Specific Rotations.

Journal of natural products·2021
Same author

My 60-Year Love Affair with Natural Products.

Journal of natural products·2021
Same author

Flavanones from the Twigs and Barks of Artocarpus lakoocha Having Antiplasmodial and Anti-TB Activities.

Chemical & pharmaceutical bulletin·2020

Related Experiment Video

Updated: Feb 9, 2026

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Published on: September 23, 2017

9.6K

What makes epothilones stick?

David G I Kingston1

  • 1Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

Chemistry & Biology
|May 5, 2004
PubMed
Summary

Epothilones are potent promoters of tubulin polymerization. This study provides new mechanistic insights into how epothilones affect tubulin polymerization, deepening our understanding of their action.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Epothilones are a class of microtubule-targeting agents.
  • Their potent tubulin polymerization-promoting activity has been extensively studied.
  • Previous research focused on synthetic and structure-activity relationship (SAR) approaches.

Purpose of the Study:

  • To provide a deeper mechanistic understanding of epothilone action.
  • To analyze the tubulin polymerization mechanism of epothilones.
  • To elucidate how epothilones interact with tubulin.

Main Methods:

  • Detailed analysis of the tubulin polymerization process.
  • Biophysical techniques to study protein-protein interactions.
  • Biochemical assays to quantify polymerization rates.

More Related Videos

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.7K
Finger-stick Blood Sampling Methodology for the Determination of Exercise-induced Lymphocyte Apoptosis
04:37

Finger-stick Blood Sampling Methodology for the Determination of Exercise-induced Lymphocyte Apoptosis

Published on: February 24, 2011

12.5K

Related Experiment Videos

Last Updated: Feb 9, 2026

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Published on: September 23, 2017

9.6K
Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.7K
Finger-stick Blood Sampling Methodology for the Determination of Exercise-induced Lymphocyte Apoptosis
04:37

Finger-stick Blood Sampling Methodology for the Determination of Exercise-induced Lymphocyte Apoptosis

Published on: February 24, 2011

12.5K

Main Results:

  • Epothilones stabilize microtubules by promoting tubulin polymerization.
  • The study identified key steps in the epothilone-induced polymerization mechanism.
  • Quantitative data on the effects of epothilones on microtubule dynamics were obtained.

Conclusions:

  • Epothilones exert their potent effects through a specific mechanism of tubulin polymerization promotion.
  • This work enhances the mechanistic understanding of epothilone-tubulin interactions.
  • The findings contribute to the development of novel microtubule-targeting cancer therapies.