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Updated: Aug 15, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
Reversal of an antihistamine-induced coma with flumazenil
Alvaro Lassaletta1, Ricardo Martino, Pilar Gónzalez-Santiago
1Department of Pediatrics, Príncipe de Asturias University Hospital, Alcalá de Henares, Madrid, Spain. lassaalvaro@yahoo.com
Abstract:
Flumazenil is a competitive antagonist with specific action at the central benzodiazepine receptor. It is used when benzodiazepine intoxication is suspected. Its use has also been reported in cannabis intoxication, chloral hydrate overdose, hepatic encephalopathy, and alcohol intoxication. We report the case of a 7-month-old male infant with a depressed level of consciousness after intentional intoxication of antihistamines, whose mental status fully recovered after administration of flumazenil. To our knowledge, this is the first case in children where flumazenil has been reported to reverse antihistamine-induced coma.
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