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Buccal mucosal graft for urethral reconstruction
Hung Jen Wang1, Po Hui Chiang, Fang Pin Lee
1Department of Urology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Summary
Buccal mucosa grafts offer a promising solution for urethral reconstruction, addressing limitations of traditional grafts like skin and bladder tissue. This technique shows effectiveness in complex cases, with good long-term outcomes for patients with urethral defects.
Area of Science:
- Urology
- Regenerative Medicine
- Tissue Engineering
Background:
- Traditional grafts for urethral reconstruction (skin, bladder mucosa) can lead to strictures and meatal prolapse.
- Alternative graft materials are needed for successful urethral defect repair when primary anastomosis fails.
Observation:
- Buccal mucosa was utilized for urethral reconstruction in three patients with complex urethral defects.
- One patient received a tube graft for hypospadias repair, while two received onlay grafts for necrosis and stricture.
Findings:
- All three patients remained disease-free during a mean follow-up of 36 months (range, 12-49 months).
- A minor pinhole fistula in one patient was successfully treated with simple repair, indicating good graft integration and healing.
Implications:
- Buccal mucosa grafting presents a viable and effective alternative for urethral reconstruction, particularly when local grafts are unsuitable.
- This technique demonstrates potential for managing complicated urethral defects, offering a durable solution with minimal complications.