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Updated: Aug 24, 2026

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
Published on: June 28, 2019
The hemolytic activity of epoxydammarane triterpenoids
N G Prokof'eva1, M M Anisimov, E B Shentsova
1Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russian Federation.
Abstract:
The hemolytic activity of the epoxydammarane triterpenoids isolated from the Far-East species of the genus Betula and their semi-synthetic derivatives was investigated. Comparative studies of epoxydammarane triterpenoid activities at pH 5.5 and 5.0 and at 37 and 42 degrees C showed that 3-oxo, 3,11-dioxo, 3- and 11-acetoxy, as well as 3,11-diacetoxy derivatives had hemolytic potencies lower than the corresponding polyols; triterpenoids with a 3alpha-OH group were stronger than their analogues with a 3beta-OH group; epoxydammaranetriols were somewhat more potent than epoxydammaranediols. Triterpenoids esterified with malonic acid at C-3 possessed the strongest hemolytic activity among the tested compounds.
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