Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in central and peripheral nervous system function during hypoglycemia in man: an electro-physiological

G Tamburrano1, N Locuratolo, G Pozzessere

  • 1Cattedra di Endocrinologia I, Università di Roma La Sapienza, Italy.

Journal of Endocrinological Investigation
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence-based recommendations for the use of continuous glucose monitoring in type 2 diabetes: the Italian guidelines.

Acta diabetologica·2026
Same author

Author Correction: Continuous radon monitoring during seven years of volcanic unrest at Campi Flegrei caldera (Italy).

Scientific reports·2026
Same author

Time-activity budget in horses and ponies: A systematic review and meta-analysis on feeding dynamics and management implications.

Journal of equine veterinary science·2025
Same author

Universal Prevention of Dementia in Italy: A Document Analysis of the 21 Italian Regional Prevention Plans.

The journal of prevention of Alzheimer's disease·2024
Same author

Covid-19 infection in pregnant women: Auditory evaluation in infants.

Journal of neonatal-perinatal medicine·2024
Same author

Effectiveness of oral semaglutide on glucose control and body weight up to 18 months: a multicenter retrospective real-world study.

Journal of endocrinological investigation·2024

Hypoglycemia does not affect peripheral nerve function in healthy individuals. However, prolonged low blood sugar significantly slows central somatosensory pathway conduction, impacting brain signaling.

Area of Science:

  • Neuroscience
  • Electrophysiology
  • Endocrinology

Background:

  • Somatosensory evoked potentials (SEP) assess the integrity of the somatosensory nervous system.
  • Hypoglycemia, or low blood sugar, can potentially affect neurological function.
  • Understanding the impact of hypoglycemia on neural pathways is crucial for managing metabolic disorders.

Purpose of the Study:

  • To investigate the effects of acute and prolonged hypoglycemia on somatosensory evoked potentials (SEP) in healthy subjects.
  • To determine if hypoglycemia influences peripheral nerve conduction velocity or central somatosensory pathway conduction time.
  • To identify the threshold for hypoglycemia-induced changes in central nervous system electrophysiology.

Main Methods:

  • Measurement of SEP parameters including peripheral conduction velocity (wrist-Erb CV), brachial plexus to cervical cord conduction time (Erb-N13), and central conduction time (N13-N20).

Related Experiment Videos

  • Comparison of electrophysiological data between a group experiencing acute hypoglycemia (Group A) and a group experiencing moderately prolonged hypoglycemia (Group B).
  • Statistical analysis to determine significant changes in conduction parameters during hypoglycemic conditions.

    • Main Results:

    • No significant changes in electrophysiological parameters were observed in Group A (acute hypoglycemia).
    • In Group B (prolonged hypoglycemia), a significant increase in central conduction time (N13-N20) was recorded, rising from baseline values.
    • Hypoglycemia levels as low as 2.4 mmol/L, sustained for over 60 minutes, were associated with increased central somatosensory pathway conduction time.

    Conclusions:

    • Acute and moderately prolonged hypoglycemia do not impair peripheral nerve function in healthy individuals.
    • Sustained hypoglycemia exceeding 60 minutes significantly delays conduction within central somatosensory pathways.
    • These findings highlight the sensitivity of central neural pathways to prolonged low blood glucose levels.