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Protothecosis.

Beatriz Consuelo Quinet Leimann1, Paulo Cezar Fialho Monteiro, Márcia Lazéra

  • 1Mycology Service, Evandro Chagas Institute of Clinical Research, IPEC/FIOCRUZ, Rio de Janeiro, Brazil. leimann@centroin.com.br

Medical Mycology
|May 6, 2004
PubMed
Summary
This summary is machine-generated.

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Protothecosis, a rare human infection from Prototheca algae, typically affects the skin. This case highlights fluconazole as a potential treatment for cutaneous protothecosis when other antifungals fail.

Area of Science:

  • Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Protothecosis is a rare infection caused by achlorophyllic algae of the genus Prototheca.
  • Human cases are uncommon, with approximately 100 documented instances, predominantly caused by Prototheca wickerhamii.
  • Cutaneous manifestations are the most frequent presentation of human protothecosis.

Observation:

  • A 59-year-old female patient presented with cutaneous protothecosis on her right fourth finger.
  • The patient had no significant underlying medical conditions.
  • Initial treatment with itraconazole (400 mg/day for 6 weeks) yielded an inadequate clinical response.

Findings:

  • Diagnosis was confirmed through standard microbiological and histopathological methods.

Related Experiment Videos

  • Subsequent treatment with fluconazole (200 mg/day) resulted in lesion regression.
  • This suggests fluconazole may be effective in treating cutaneous protothecosis.

    • Implications:

    • The study contributes to the limited understanding of effective therapeutic strategies for protothecosis.
    • Fluconazole emerges as a viable alternative treatment option for recalcitrant cutaneous protothecosis.
    • Further research is warranted to establish definitive treatment guidelines for this rare fungal infection.