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Sarcoidosis in untreated chronic hepatitis C virus infection
F Tsimpoukas1, C Goritsas, N Papadopoulos
1Dept. of Internal Medicine, Sotiria General Hospital of Athens, Athens, Greece. fotistsi@otenet.gr
Abstract:
Chronic hepatitis C has been implicated in the pathogenesis of sarcoidosis in several cases of patients treated with interferon-alpha. On the other hand, only in a few cases previously has a possible link between sarcoidosis and untreated chronic hepatitis C virus infection been demonstrated. We report on a patient with chronic hepatitis C who developed cutaneous sarcoidosis without prior interferon-alpha treatment. We hypothesize that viral persistence seen in chronic hepatitis C virus infection might be one of the potential factors that trigger cellular immune response in granulomatous reactions as seen in sarcoidosis, in genetically predisposed patients.
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