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Updated: Jul 16, 2026

In-vivo Detection of Protein-protein Interactions on Micro-patterned Surfaces
Published on: March 19, 2010
Pattern-based detection of different proteins using an array of fluorescent protein surface receptors
Laura Baldini1, Andrew J Wilson, Jason Hong
1Department of Chemistry, Yale University, P.O. Box 208107, 225 Prospect Street, New Haven, Connecticut 06520-8107, USA.
Abstract:
A small library of porphyrin derivatives whose fluorescence emission changes on binding to protein surfaces has been developed as a protein "fingerprinting" array. When incubated with different proteins, the array yields a characteristic response, specific for every protein analyte. At the same time, this design allows for the rapid screening of the porphyrin library for the identification of high affinity protein surface ligands.
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