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A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
Published on: February 27, 2019
Solid-phase synthesis of kojic acid-tripeptides and their tyrosinase inhibitory activity, storage stability, and
Hanyoung Kim1, Jaehui Choi, Jin Ku Cho
1School of Chemical Engineering, Seoul National University, Seoul 151-744, South Korea.
Bioorganic & Medicinal Chemistry Letters
|May 6, 2004
Abstract:
A small library of kojic acid-tripeptides (Ko-X1X2X3) was prepared by solid-phase parallel synthesis and assayed to evaluate their tyrosinase inhibitory activity. Most of the kojic acid-tripeptides showed better activities than kojic acid. Kojic acid-FWY was the best compound, and it exhibited 100-fold tyrosinase inhibitory activity compared with kojic acid. In addition, their storage stabilities were approximately 15 times higher and their toxicity was lower than that of kojic acid.
