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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Lipid II-mediated pore formation by the peptide antibiotic nisin: a black lipid membrane study
Imke Wiedemann1, Roland Benz, Hans-Georg Sahl
1Institut für Medizinische Mikrobiologie und Immunologie der Universität Bonn, D-53105 Bonn, Germany. imke.wiedemann@ukb.uni-bonn.de
Journal of Bacteriology
|May 6, 2004
Abstract:
The antibiotic peptide nisin is the first known lantibiotic that uses a docking molecule within the bacterial cytoplasmic membrane for pore formation. Through specific interaction with the cell wall precursor lipid II, nisin forms defined pores which are stable for seconds and have pore diameters of 2 to 2.5 nm.
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