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Updated: Aug 24, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Bielschowskysin, a gorgonian-derived biologically active diterpene with an unprecedented carbon skeleton
Jeffrey Marrero1, Abimael D Rodríguez, Peter Baran
1Department of Chemistry, University of Puerto Rico, PO Box 23346, U.P.R. Station, San Juan, Puerto Rico 00931-3346.
Abstract:
Bielschowskysin is a naturally occurring diterpene isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure is based on a previously undescribed tricyclo[9.3.0.0(2,10)]tetradecane ring system that was established through spectroscopic analysis and X-ray crystallographic analysis. Bielschowskysin was shown to exhibit antimalarial activity against Plasmodium falciparum as well as strong anticancer activity against two human cancer cell lines.
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