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Fatal Evans' syndrome after matched unrelated donor transplantation for hyper-IgM syndrome

Christan Urban1, Martin Benesch, Petra Sovinz

  • 1Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Graz, Graz, Austria.

European Journal of Haematology
|May 7, 2004
PubMed

A 3 and 1/2-yr-old boy underwent matched unrelated stem cell transplantation (SCT) for hyper-IgM syndrome. He developed acute and chronic skin graft-vs.-host disease (GVHD). Ten months following SCT he presented with severe hemolytic anemia and thrombocytopenia (Evans' syndrome). Treatment included high-dose steroids, intravenous immunoglobulins, cyclosporine, mycophenolate mofetil, chemotherapeutic agents (cyclophosphamide, vincristine, VP-16), immunoadsorption, and anti-CD20 and anti-CD52 monoclonal antibodies without response. The patient died 16 months after SCT.

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