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Intravesical electrical stimulation--an experimental analysis of the mechanism of action
A Ebner1, C Jiang, S Lindström
1Department of Urology, University Clinic, Innsbruck, Austria.
The Journal of Urology
|September 1, 1992
Abstract:
The working mechanism of intravesical electrical stimulation (IVES) was evaluated in alpha-chloralose anaesthetized cats and rats. IVES involved a direct activation of bladder mechanoreceptor afferents of the A delta type and as a consequence a central reflex activation of the detrusor. The detrusor response was abolished by bilateral transection of the S1-S3 dorsal roots and by intravesical instillation of lidocaine. The optimal stimulation frequency was 20 Hz. The results offer a theoretical rationale for the use of IVES as treatment of weak detrusor contractility in man.